New drugs targeting the cell envelope of Mycobacterium tuberculosis

Conférence du Dr Mary Jackson (Colorado State University, USA)

Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) in humans, currently infects one‐third of the world's population in its latent form and claims about 1.7 million lives annually making it a leader among the causes of mortality in developing countries. New chemotherapeutics active against multidrug‐resistant Mtb are urgently needed.

This talk will summarize the various strategies that have been used over the years towards anti‐TB drug discovery and the current trends in the field. The recent discovery of inhibitors targeting some essential and novel aspects of the cell envelope biosynthesis of Mtb will illustrate this topic.

Informations

Conférencier invité par le Dr J. Sygusch, du Département de biochimie de la Faculté de médecine.